Chemicals and Drugs

Methadone

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Chemical Identity

Chemical Information

Molecular Formula
C21H27NO
Molecular Weight
309.4 g/mol
CAS Registry No.
76-99-3
IUPAC Name
6-(dimethylamino)-4,4-diphenylheptan-3-one
InChIKey
USSIQXCVUWKGNF-UHFFFAOYSA-N
SMILES
CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
MeSH Unique ID
D008691
Source
PubChem CID 4095

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

15 entry terms
  • Amidone
  • Biodone
  • Dolophine
  • Metadol
  • Metasedin
  • Methaddict
  • Methadone Hydrochloride
  • Methadose
  • Methex
  • Phenadone
  • Phymet
  • Physeptone
  • Pinadone
  • Symoron
  • Hydrochloride, Methadone

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

for methadone maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT

MeSH Hierarchy

Tree Number

  1. D02w.522w.675w

AMA Style

References

  1. National Library of Medicine. Methadone. Medical Subject Headings (MeSH). 2026. Unique ID D008691. http://id.nlm.nih.gov/mesh/2026/D008691
  2. Methadone. In: Wikipedia. https://en.wikipedia.org/wiki/Methadone
  3. Methadone. In: Wikidata. https://www.wikidata.org/wiki/Q179996
  4. Methadone. In: PubChem Compound. CID 4095. https://pubchem.ncbi.nlm.nih.gov/compound/4095