Structured Summary
Abstract
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
Chemical Identity
Chemical Information
- Molecular Formula
- C4H6O4
- Molecular Weight
- 118.09 g/mol
- CAS Registry No.
- 516-05-2
- IUPAC Name
- 2-methylpropanedioic acid
- InChIKey
- ZIYVHBGGAOATLY-UHFFFAOYSA-N
- SMILES
- CC(C(=O)O)C(=O)O
- MeSH Unique ID
- D008764
- Source
- PubChem CID 487
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
1 entry terms
- Acid, Methylmalonic
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
/biosyn /physiol permitted
MeSH Record
History Note
91(75); was see under MALONATES 1975-90
MeSH Record
Previous Indexing
- Malonates (1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Methylmalonic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D008764. http://id.nlm.nih.gov/mesh/2026/D008764
- Methylmalonic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Methylmalonic_acid
- Methylmalonic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q239598
- Methylmalonic Acid. In: PubChem Compound. CID 487. https://pubchem.ncbi.nlm.nih.gov/compound/487