Chemicals and Drugs

Methylphenidate

A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.

Chemical Identity

Chemical Information

Molecular Formula
C14H19NO2
Molecular Weight
233.31 g/mol
CAS Registry No.
113-45-1
IUPAC Name
methyl 2-phenyl-2-piperidin-2-ylacetate
InChIKey
DUGOZIWVEXMGBE-UHFFFAOYSA-N
SMILES
COC(=O)C(C1CCCCN1)C2=CC=CC=C2
MeSH Unique ID
D008774
Source
PubChem CID 4158

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • Centedrin
  • Concerta
  • Daytrana
  • Equasym
  • Metadate
  • Methylin
  • Methylphenidate Hydrochloride
  • Phenidylate
  • Ritalin
  • Ritalin-SR
  • Ritaline
  • Tsentedrin
  • Hydrochloride, Methylphenidate
  • Ritalin SR

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

PHENIDYLATE was see METHYLPHENIDATE 1978-94

MeSH Hierarchy

Tree Numbers

  1. D02w.241w.223.601.600w
  2. D03w.383.621.460w

AMA Style

References

  1. National Library of Medicine. Methylphenidate. Medical Subject Headings (MeSH). 2026. Unique ID D008774. http://id.nlm.nih.gov/mesh/2026/D008774
  2. Methylphenidate. In: Wikipedia. https://en.wikipedia.org/wiki/Methylphenidate
  3. Methylphenidate. In: Wikidata. https://www.wikidata.org/wiki/Q422112
  4. Methylphenidate. In: PubChem Compound. CID 4158. https://pubchem.ncbi.nlm.nih.gov/compound/4158