Chemicals and Drugs

Methysergide

An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.

Chemical Identity

Chemical Information

Molecular Formula
C21H27N3O2
Molecular Weight
353.5 g/mol
CAS Registry No.
361-37-5
IUPAC Name
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
InChIKey
KPJZHOPZRAFDTN-ZRGWGRIASA-N
SMILES
CC[C@@H](CO)NC(=O)[C@H]1CN([C@@H]2CC3=CN(C4=CC=CC(=C34)C2=C1)C)C
MeSH Unique ID
D008784
Source
PubChem CID 9681

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

14 entry terms
  • Dimethylergometrin
  • Methylmethylergonovine
  • Deseril
  • Desril
  • Désernil-Sandoz
  • Methysergide Dimaleate
  • Methysergide Maleate
  • Sansert
  • UML-491
  • Dimaleate, Methysergide
  • Désernil Sandoz
  • Maleate, Methysergide
  • UML 491
  • UML491

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

65(63); METHYSERGIDE DERIVATIVES was see under METHYSERGIDE 1975-77; was see under ERGOLINES 1969-74

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.327.287.689w
  2. D03w.633.400.439.689w

AMA Style

References

  1. National Library of Medicine. Methysergide. Medical Subject Headings (MeSH). 2026. Unique ID D008784. http://id.nlm.nih.gov/mesh/2026/D008784
  2. Methysergide. In: Wikipedia. https://en.wikipedia.org/wiki/Methysergide
  3. Methysergide. In: Wikidata. https://www.wikidata.org/wiki/Q424442
  4. Methysergide. In: PubChem Compound. CID 9681. https://pubchem.ncbi.nlm.nih.gov/compound/9681