Chemicals and Drugs

MicroRNAs

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

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Synonyms

17 entry terms
  • Micro RNA
  • MicroRNA
  • miRNA
  • miRNAs
  • RNA, Micro
  • Primary MicroRNA
  • Primary miRNA
  • RNA, Small Temporal
  • Small Temporal RNA
  • pre-miRNA
  • pri-miRNA
  • stRNA
  • MicroRNA, Primary
  • Temporal RNA, Small
  • miRNA, Primary
  • pre miRNA
  • pri miRNA

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use MICRORNAS (NM) 2001-2002

MeSH Record

Previous Indexing

  • RNA, Antisense (2001-2002)
  • RNA, Untranslated (2001-2002)

MeSH Hierarchy

Tree Numbers

  1. D13.150.650w.319w
  2. D13.444w.735w.150w.319w
  3. D13.444w.735w.790.552.500w

AMA Style

References

  1. National Library of Medicine. MicroRNAs. Medical Subject Headings (MeSH). 2026. Unique ID D035683. http://id.nlm.nih.gov/mesh/2026/D035683
  2. MicroRNAs. In: Wikipedia. https://en.wikipedia.org/wiki/MicroRNA
  3. MicroRNAs. In: Wikidata. https://www.wikidata.org/wiki/Q310899