Chemicals and Drugs

Midkine

A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

3 entry terms
  • Amphiregulin-Associated Protein
  • Cytokine MK
  • Amphiregulin Associated Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2019 (1991)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.854
  2. D12.776w.467.848
  3. D23.529.831

AMA Style

References

  1. National Library of Medicine. Midkine. Medical Subject Headings (MeSH). 2026. Unique ID D000078792. http://id.nlm.nih.gov/mesh/2026/D000078792
  2. Midkine. In: Wikidata. https://www.wikidata.org/wiki/Q4292840