Diseases

Miller Fisher Syndrome

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • Fisher Syndrome
  • Guillain Barre Syndrome, Miller Fisher Variant
  • Guillain-Barre Syndrome, Miller Fisher Variant
  • Miller Fisher Variant of Guillain Barre Syndrome
  • Miller-Fisher Syndrome
  • Ophthalmoplegia, Ataxia and Areflexia Syndrome
  • Syndrome, Fisher
  • Syndrome, Miller Fisher
  • Syndrome, Miller-Fisher

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

entry term FISHER SYNDROME: do not confuse with the Fisher one-and-a-half syndrome, an eye movement disorder caused by a brain stem lesion

MeSH Record

History Note

1998

MeSH Record

Previous Indexing

  • Cerebellar Ataxia (1970-1997)
  • Ophthalmoplegia (1966-1997)
  • Polyradiculitis (1966-1984)
  • Polyradiculoneuritis (1981-1997)
  • Reflex, Abnormal (1966-1997)

MeSH Hierarchy

Tree Numbers

  1. C10w.114.750w.100w.500
  2. C10w.228w.140w.252.500
  3. C10w.292w.562.350
  4. C10w.314w.750w.450w.500
  5. C10w.668w.829w.800w.750w.300w.500
  6. C11w.590.312
  7. C20w.111w.258.750w.400w.500

AMA Style

References

  1. National Library of Medicine. Miller Fisher Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D019846. http://id.nlm.nih.gov/mesh/2026/D019846
  2. Miller Fisher Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q449631