Structured Summary
Abstract
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Chemical Identity
Chemical Information
- Molecular Formula
- C12H9N3O
- Molecular Weight
- 211.22 g/mol
- CAS Registry No.
- 78415-72-2
- IUPAC Name
- 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
- InChIKey
- PZRHRDRVRGEVNW-UHFFFAOYSA-N
- SMILES
- CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
- MeSH Unique ID
- D020105
- Source
- PubChem CID 4197
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- Corotrop
- Corotrope
- Milrinone Lactate
- Primacor
- Win-47203
- Lactate, Milrinone
- Win 47203
- Win47203
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
1999; use MILRINONE (NM) 1983-1998
MeSH Record
Previous Indexing
- Pyridones (1983-1998)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Milrinone. Medical Subject Headings (MeSH). 2026. Unique ID D020105. http://id.nlm.nih.gov/mesh/2026/D020105
- Milrinone. In: Wikipedia. https://en.wikipedia.org/wiki/Milrinone
- Milrinone. In: Wikidata. https://www.wikidata.org/wiki/Q847399
- Milrinone. In: PubChem Compound. CID 4197. https://pubchem.ncbi.nlm.nih.gov/compound/4197