Structured Summary
Abstract
A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
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Synonyms
3 entry terms
- Mitochondrial Megachannel
- Mitochondrial Permeability Transition Pore (mPTP)
- mPTP Protein
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2021(1999)
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References
- National Library of Medicine. Mitochondrial Permeability Transition Pore. Medical Subject Headings (MeSH). 2026. Unique ID D000083162. http://id.nlm.nih.gov/mesh/2026/D000083162
- Mitochondrial Permeability Transition Pore. In: Wikipedia. https://en.wikipedia.org/wiki/Mitochondrial_permeability_transition_pore
- Mitochondrial Permeability Transition Pore. In: Wikidata. https://www.wikidata.org/wiki/Q6881880