Structured Summary
Abstract
A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Chemical Identity
Chemical Information
- Molecular Formula
- C14H10Cl4
- Molecular Weight
- 320.0 g/mol
- CAS Registry No.
- 53-19-0
- IUPAC Name
- 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
- InChIKey
- JWBOIMRXGHLCPP-UHFFFAOYSA-N
- SMILES
- C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
- MeSH Unique ID
- D008939
- Source
- PubChem CID 4211
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- Mytotan
- o,p-DDD
- ortho,para-DDD
- ortho,para DDD
- Chloditan
- Chlodithane
- Khloditan
- Lysodren
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
73
MeSH Record
Previous Indexing
- DDD/PD (1966-1972)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Mitotane. Medical Subject Headings (MeSH). 2026. Unique ID D008939. http://id.nlm.nih.gov/mesh/2026/D008939
- Mitotane. In: Wikipedia. https://en.wikipedia.org/wiki/Mitotane
- Mitotane. In: Wikidata. https://www.wikidata.org/wiki/Q417465
- Mitotane. In: PubChem Compound. CID 4211. https://pubchem.ncbi.nlm.nih.gov/compound/4211