Chemicals and Drugs

Monoamine Oxidase

An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.

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MeSH Record

Synonyms

13 entry terms
  • Amine Oxidase (Flavin-Containing)
  • MAO
  • Tyramine Oxidase
  • Oxidase, Monoamine
  • Oxidase, Tyramine
  • MAO-A
  • MAO-B
  • Monoamine Oxidase A
  • Monoamine Oxidase B
  • Type A Monoamine Oxidase
  • Type B Monoamine Oxidase
  • MAO A
  • MAO B

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Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

63; for TYRAMINE OXIDASE use MONOAMINE OXIDASE (NM) 1980-98

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.664.750w

MeSH Record

NLM Classification

QU 140

AMA Style

References

  1. National Library of Medicine. Monoamine Oxidase. Medical Subject Headings (MeSH). 2026. Unique ID D008995. http://id.nlm.nih.gov/mesh/2026/D008995
  2. Monoamine Oxidase. In: Wikipedia. https://en.wikipedia.org/wiki/Monoamine_oxidase
  3. Monoamine Oxidase. In: Wikidata. https://www.wikidata.org/wiki/Q410867