Chemicals and Drugs

Moxalactam

Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.

Chemical Identity

Chemical Information

Molecular Formula
C20H20N6O9S
Molecular Weight
520.5 g/mol
CAS Registry No.
64952-97-2
IUPAC Name
(6R,7R)-7-[[2-carboxy-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey
JWCSIUVGFCSJCK-CAVRMKNVSA-N
SMILES
CN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@](C3=O)(NC(=O)C(C4=CC=C(C=C4)O)C(=O)O)OC)OC2)C(=O)O
MeSH Unique ID
D009070
Source
PubChem CID 47499

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

22 entry terms
  • Lamoxactam
  • Latamoxef
  • 1-Oxacephalosporin
  • 6059-S
  • Disodium Latamoxef
  • Disodium Moxalactam
  • Festamoxin
  • Lilly 127935
  • Ly-127935
  • Ly127935
  • Moxalactam Disodium
  • S-6059
  • Shiomarin
  • 1 Oxacephalosporin
  • 6059 S
  • 6059S
  • Disodium, Moxalactam
  • Latamoxef, Disodium
  • Ly 127935
  • Moxalactam, Disodium
  • S 6059
  • S6059

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

84

MeSH Record

Previous Indexing

  • Antibiotics (1966-1980)
  • Cefamandole/analogs & derivatives (1978-1983)
  • Cephalosporins (1966-1974)
  • Cephamycins (1975-1977)
  • Lactams (1972-1980)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.589w.099w.625w
  2. D02w.886w.520w.575w
  3. D03w.633.100.300w.625w

MeSH Record

NLM Classification

QV 350

AMA Style

References

  1. National Library of Medicine. Moxalactam. Medical Subject Headings (MeSH). 2026. Unique ID D009070. http://id.nlm.nih.gov/mesh/2026/D009070
  2. Moxalactam. In: Wikipedia. https://en.wikipedia.org/wiki/Latamoxef
  3. Moxalactam. In: Wikidata. https://www.wikidata.org/wiki/Q3827439
  4. Moxalactam. In: PubChem Compound. CID 47499. https://pubchem.ncbi.nlm.nih.gov/compound/47499