Phenomena and Processes

Muscle Fatigue

A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

MeSH Record

Classification

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See Also

MeSH Record

Synonyms

3 entry terms
  • Fatigue, Muscle
  • Muscular Fatigue
  • Fatigue, Muscular

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

Indexing Annotation

note category

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Fatigue (1966-1994)
  • Muscles (1966-1994)
  • specific muscle (1966-1994)

MeSH Hierarchy

Tree Number

  1. G11.427.550w

AMA Style

References

  1. National Library of Medicine. Muscle Fatigue. Medical Subject Headings (MeSH). 2026. Unique ID D018763. http://id.nlm.nih.gov/mesh/2026/D018763
  2. Muscle Fatigue. In: Wikipedia. https://en.wikipedia.org/wiki/Muscle_fatigue
  3. Muscle Fatigue. In: Wikidata. https://www.wikidata.org/wiki/Q6940317