Chemicals and Drugs

Mycophenolic Acid

Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.

Chemical Identity

Chemical Information

Molecular Formula
C17H20O6
Molecular Weight
320.3 g/mol
CAS Registry No.
24280-93-1
IUPAC Name
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
InChIKey
HPNSFSBZBAHARI-RUDMXATFSA-N
SMILES
CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O
MeSH Unique ID
D009173
Source
PubChem CID 446541

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

13 entry terms
  • Cellcept
  • Mycophenolate Mofetil
  • Mycophenolate Mofetil Hydrochloride
  • Mycophenolate Sodium
  • Mycophenolic Acid Morpholinoethyl Ester
  • Myfortic
  • RS 61443
  • RS-61443
  • Sodium Mycophenolate
  • Mofetil Hydrochloride, Mycophenolate
  • Mofetil, Mycophenolate
  • Mycophenolate, Sodium
  • RS61443

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2017 (1999)

MeSH Record

Previous Indexing

  • Antibiotics, Antineoplastic (1967-1971)
  • Caproates (1967-1971)

MeSH Hierarchy

Tree Numbers

  1. D02w.241w.081.193.678w
  2. D10w.251w.618w

AMA Style

References

  1. National Library of Medicine. Mycophenolic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D009173. http://id.nlm.nih.gov/mesh/2026/D009173
  2. Mycophenolic Acid. In: Wikipedia. https://en.wikipedia.org/wiki/Mycophenolic_acid
  3. Mycophenolic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q420553
  4. Mycophenolic Acid. In: PubChem Compound. CID 446541. https://pubchem.ncbi.nlm.nih.gov/compound/446541