Chemicals and Drugs

Myristoylated Alanine-Rich C Kinase Substrate

A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • ACAMP-81
  • MARCKS Protein
  • Myristoylated Alanine Rich C Kinase Substrate

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1989)

MeSH Hierarchy

Tree Numbers

  1. D05.750w.078w.730.556
  2. D12.644w.360.537
  3. D12.776w.157w.142w.375
  4. D12.776w.157w.687.496
  5. D12.776w.220.525.556
  6. D12.776w.476.539
  7. D12.776w.543w.637
  8. D12.776w.660w.720.496

AMA Style

References

  1. National Library of Medicine. Myristoylated Alanine-Rich C Kinase Substrate. Medical Subject Headings (MeSH). 2026. Unique ID D000076250. http://id.nlm.nih.gov/mesh/2026/D000076250
  2. Myristoylated Alanine-Rich C Kinase Substrate. In: Wikidata. https://www.wikidata.org/wiki/Q24772434