Chemicals and Drugs

N-Myc Proto-Oncogene Protein

A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

9 entry terms
  • BHLHE37 Protein
  • Class E Basic Helix-Loop-Helix Protein 37
  • MYCN Protein
  • N-Myc Protein
  • NMYC Protein
  • Class E Basic Helix Loop Helix Protein 37
  • N Myc Protein
  • N Myc Proto Oncogene Protein
  • Proto-Oncogene Protein, N-Myc

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Nuclear Proteins (2002-2016)
  • Oncogene Proteins (2002-2016)
  • Proto-Oncogene Proteins (2012-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.103w.500w.625
  2. D12.776w.260w.108.092w.625
  3. D12.776w.624.664.700.158
  4. D12.776w.930w.125w.500w.563
  5. D12.776w.930w.127.092w.625

AMA Style

References

  1. National Library of Medicine. N-Myc Proto-Oncogene Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071447. http://id.nlm.nih.gov/mesh/2026/D000071447
  2. N-Myc Proto-Oncogene Protein. In: Wikidata. https://www.wikidata.org/wiki/Q6951383