Chemicals and Drugs

Nalbuphine

A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.

Chemical Identity

Chemical Information

Molecular Formula
C21H27NO4
Molecular Weight
357.4 g/mol
CAS Registry No.
20594-83-6
IUPAC Name
(4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol
InChIKey
NETZHAKZCGBWSS-CEDHKZHLSA-N
SMILES
C1CC(C1)CN2CC[C@]34[C@@H]5[C@H](CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O)O
MeSH Unique ID
D009266
Source
PubChem CID 5311304

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • EN-2234A
  • Nalbuphine Hydrochloride
  • Nalbuphine Serb
  • Nubain
  • EN 2234A
  • EN2234A

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1991 (1972)

MeSH Record

Previous Indexing

  • Morphinans (1966-1971)
  • Narcotic Antagonists (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.606w
  2. D03w.605.497.639w
  3. D03w.633.400.686.639w
  4. D04w.615w.723w.795.606w

MeSH Record

NLM Classification

QV 92

AMA Style

References

  1. National Library of Medicine. Nalbuphine. Medical Subject Headings (MeSH). 2026. Unique ID D009266. http://id.nlm.nih.gov/mesh/2026/D009266
  2. Nalbuphine. In: Wikipedia. https://en.wikipedia.org/wiki/Nalbuphine
  3. Nalbuphine. In: Wikidata. https://www.wikidata.org/wiki/Q277979
  4. Nalbuphine. In: PubChem Compound. CID 5311304. https://pubchem.ncbi.nlm.nih.gov/compound/5311304