Chemicals and Drugs

Naloxone

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

Chemical Identity

Chemical Information

Molecular Formula
C19H21NO4
Molecular Weight
327.4 g/mol
CAS Registry No.
465-65-6
IUPAC Name
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
InChIKey
UZHSEJADLWPNLE-GRGSLBFTSA-N
SMILES
C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O
MeSH Unique ID
D009270
Source
PubChem CID 5284596

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

24 entry terms
  • MRZ 2593-Br
  • MRZ-2593
  • Nalone
  • Naloxon Curamed
  • Naloxon-Ratiopharm
  • Naloxone Abello
  • Naloxone Hydrobromide
  • Naloxone Hydrochloride
  • Naloxone Hydrochloride Dihydride
  • Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
  • Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
  • Narcan
  • Narcanti
  • Abello, Naloxone
  • Curamed, Naloxon
  • Dihydride, Naloxone Hydrochloride
  • Hydrobromide, Naloxone
  • Hydrochloride Dihydride, Naloxone
  • Hydrochloride, Naloxone
  • MRZ 2593
  • MRZ 2593 Br
  • MRZ 2593Br
  • MRZ2593
  • Naloxon Ratiopharm

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1973(1972); for MRZ-2593 use OXYMORPHONE 1985-2009

MeSH Record

Previous Indexing

  • Morphinans (1969-1971)
  • Narcotic Antagonists (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.577.249.706w
  2. D03w.605.497.750w
  3. D03w.633.400.686.750w
  4. D04w.615w.723w.795.706w

AMA Style

References

  1. National Library of Medicine. Naloxone. Medical Subject Headings (MeSH). 2026. Unique ID D009270. http://id.nlm.nih.gov/mesh/2026/D009270
  2. Naloxone. In: Wikipedia. https://en.wikipedia.org/wiki/Naloxone
  3. Naloxone. In: Wikidata. https://www.wikidata.org/wiki/Q282902
  4. Naloxone. In: PubChem Compound. CID 5284596. https://pubchem.ncbi.nlm.nih.gov/compound/5284596