Chemicals and Drugs

Natalizumab

A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • Antegren
  • Tysabri

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016 (2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.224w.060w.813w
  2. D12.776w.124w.790.651.114w.224w.060w.813w
  3. D12.776w.377w.715.548.114w.224w.200w.813w

AMA Style

References

  1. National Library of Medicine. Natalizumab. Medical Subject Headings (MeSH). 2026. Unique ID D000069442. http://id.nlm.nih.gov/mesh/2026/D000069442
  2. Natalizumab. In: Wikipedia. https://en.wikipedia.org/wiki/Natalizumab
  3. Natalizumab. In: Wikidata. https://www.wikidata.org/wiki/Q386119