Structured Summary
Abstract
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
Chemical Identity
Chemical Information
- Molecular Formula
- C12H19N2O2+
- Molecular Weight
- 223.29 g/mol
- CAS Registry No.
- 59-99-4
- IUPAC Name
- [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium
- InChIKey
- ALWKGYPQUAPLQC-UHFFFAOYSA-N
- SMILES
- CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
- MeSH Unique ID
- D009388
- Source
- PubChem CID 4456
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
11 entry terms
- Proserine
- Prozerin
- Synstigmin
- Neostigmine Bromide
- Neostigmine Methylsulfate
- Polstigmine
- Prostigmin
- Prostigmine
- Syntostigmine
- Bromide, Neostigmine
- Methylsulfate, Neostigmine
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Hierarchy
Tree Numbers
MeSH Record
NLM Classification
QV 124
AMA Style
References
- National Library of Medicine. Neostigmine. Medical Subject Headings (MeSH). 2026. Unique ID D009388. http://id.nlm.nih.gov/mesh/2026/D009388
- Neostigmine. In: Wikipedia. https://en.wikipedia.org/wiki/Neostigmine
- Neostigmine. In: Wikidata. https://www.wikidata.org/wiki/Q410546
- Neostigmine. In: PubChem Compound. CID 4456. https://pubchem.ncbi.nlm.nih.gov/compound/4456