Diseases

Nesidioblastosis

An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.

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Classification

Broader headings

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See Also

MeSH Record

Synonyms

9 entry terms
  • Hyperinsulinism, Familial, with Pancreatic Nesidioblastosis
  • Nesidioblastosis of Pancreas
  • Pancreatic Nesidioblastosis
  • Nesidioblastoses
  • Nesidioblastoses, Pancreatic
  • Nesidioblastosis, Pancreatic
  • Pancreas Nesidioblastoses
  • Pancreas Nesidioblastosis
  • Pancreatic Nesidioblastoses

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2005; use PANCREATIC DISEASES 1983-2004

MeSH Record

Previous Indexing

  • Hyperinsulinism (1971-2004)
  • Hyperplasia (1968-2004)
  • Islets of Langerhans (1968-2004)

MeSH Hierarchy

Tree Numbers

  1. C06w.689w.150w.500w
  2. C16w.614.200w.500w
  3. C18.452w.394.968w.250w.500w
  4. C18.452w.394.984w.200w.500w

AMA Style

References

  1. National Library of Medicine. Nesidioblastosis. Medical Subject Headings (MeSH). 2026. Unique ID D046768. http://id.nlm.nih.gov/mesh/2026/D046768
  2. Nesidioblastosis. In: Wikipedia. https://en.wikipedia.org/wiki/Nesidioblastosis
  3. Nesidioblastosis. In: Wikidata. https://www.wikidata.org/wiki/Q1535394