Diseases

Neural Tube Defects

Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)

MeSH Record

Classification

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MeSH Record

Synonyms

38 entry terms
  • Developmental Defects, Neural Tube
  • Developmental Neural Tube Defects
  • Neural Tube Developmental Defects
  • Defect, Neural Tube
  • Defects, Neural Tube
  • Neural Tube Defect
  • Acrania
  • Craniorachischisis
  • Diastematomyelia
  • Exencephaly
  • Iniencephaly
  • Neurenteric Cyst
  • Neuroenteric Cyst
  • Occult Spinal Dysraphism
  • Occult Spinal Dysraphism Sequence
  • Spinal Cord Myelodysplasia
  • Tethered Cord Syndrome
  • Tethered Spinal Cord Syndrome
  • Acranias
  • Craniorachischises
  • Cyst, Neurenteric
  • Cyst, Neuroenteric
  • Cysts, Neurenteric
  • Cysts, Neuroenteric
  • Diastematomyelias
  • Dysraphism, Occult Spinal
  • Dysraphisms, Occult Spinal
  • Exencephalies
  • Iniencephalies
  • Myelodysplasia, Spinal Cord
  • Myelodysplasias, Spinal Cord
  • Neurenteric Cysts
  • Neuroenteric Cysts
  • Occult Spinal Dysraphisms
  • Spinal Cord Myelodysplasias
  • Spinal Dysraphism, Occult
  • Spinal Dysraphisms, Occult
  • Tethered Cord Syndromes

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

do not confuse entry term SPINAL CORD MYELODYSPLASIA with MYELODYSPLASTIC SYNDROMES, a defect of bone marrow formation

MeSH Record

History Note

1979; for DIASTEMATOMYELIA and TETHERED CORD SYNDROME use SPINA BIFIDA OCCULTA 1991-1999; for NEURENTERIC CYST use SPINA BIFIDA OCCULTA 1991-1999, use NEURAL TUBE DEFECTS 1979-1990

MeSH Record

Previous Indexing

  • Anencephaly (1966-1978)
  • Central Nervous System (1966-1978)
  • Spina Bifida (1966-1978)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Neural Tube Defects. Medical Subject Headings (MeSH). 2026. Unique ID D009436. http://id.nlm.nih.gov/mesh/2026/D009436
  2. Neural Tube Defects. In: Wikipedia. https://en.wikipedia.org/wiki/Neural_tube_defect
  3. Neural Tube Defects. In: Wikidata. https://www.wikidata.org/wiki/Q548213