Chemicals and Drugs

Neurexins

Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2024

MeSH Record

Previous Indexing

  • Nerve Tissue Proteins (1992-2023)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.250.640w
  2. D12.776w.395w.550w.200w.250.640w
  3. D12.776w.543w.550w.200w.250.760w
  4. D12.776w.631w.609w
  5. D23.050w.301.350w.250.760w

AMA Style

References

  1. National Library of Medicine. Neurexins. Medical Subject Headings (MeSH). 2026. Unique ID D000096784. http://id.nlm.nih.gov/mesh/2026/D000096784
  2. Neurexins. In: Wikipedia. https://en.wikipedia.org/wiki/Neurexin
  3. Neurexins. In: Wikidata. https://www.wikidata.org/wiki/Q4316431