Diseases

Neurofibromatosis 2

An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

52 entry terms
  • Bilateral Acoustic Neurofibromatosis
  • Central Neurofibromatosis
  • NF2 (Neurofibromatosis 2)
  • Neurofibromatosis II
  • Neurofibromatosis Type 2
  • Neurofibromatosis Type II
  • Neurofibromatosis, Acoustic, Bilateral
  • Neurofibromatosis, Central NF2
  • Neurofibromatosis, Central, NF 2
  • Neurofibromatosis, Central, NF2
  • Neurofibromatosis, Type 2
  • Neurofibromatosis, Type II
  • Neurofibromatosis, central type
  • Acoustic Neurofibromatoses, Bilateral
  • Acoustic Neurofibromatosis, Bilateral
  • Bilateral Acoustic Neurofibromatoses
  • Central NF2 Neurofibromatoses
  • Central NF2 Neurofibromatosis
  • Central Neurofibromatoses
  • NF2s (Neurofibromatosis 2)
  • Neurofibromatoses, Bilateral Acoustic
  • Neurofibromatoses, Central
  • Neurofibromatoses, Central NF2
  • Neurofibromatoses, Type 2
  • Neurofibromatoses, Type II
  • Neurofibromatosis IIs
  • Neurofibromatosis, Bilateral Acoustic
  • Neurofibromatosis, Central
  • Type 2 Neurofibromatoses
  • Type 2 Neurofibromatosis
  • Type II Neurofibromatoses
  • Type II Neurofibromatosis
  • Acoustic Neurinoma, Bilateral
  • Acoustic Schwannomas, Bilateral
  • Familial Acoustic Neuromas
  • Neuroma, Acoustic, Bilateral
  • Schwannoma, Acoustic, Bilateral
  • Acoustic Neurinomas, Bilateral
  • Acoustic Neuroma, Familial
  • Acoustic Neuromas, Familial
  • Acoustic Schwannoma, Bilateral
  • Bilateral Acoustic Neurinoma
  • Bilateral Acoustic Neurinomas
  • Bilateral Acoustic Schwannoma
  • Bilateral Acoustic Schwannomas
  • Familial Acoustic Neuroma
  • Neurinoma, Bilateral Acoustic
  • Neurinomas, Bilateral Acoustic
  • Neuroma, Familial Acoustic
  • Neuromas, Familial Acoustic
  • Schwannoma, Bilateral Acoustic
  • Schwannomas, Bilateral Acoustic

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

do not confuse with NEUROFIBROMATOSIS 1; coord IM with precoord/neopl term (IM) if relevant

MeSH Record

History Note

1992; NEUROFIBROMATOSIS, CENTRAL, NF2 use NEUROFIBROMATOSIS, CENTRAL, NF-2 use NEUROMA, ACOUSTIC 1989-1991; NEUROMA, ACOUSTIC, BILATERAL use NEUROMA, ACOUSTIC 1989-91

MeSH Record

Previous Indexing

  • Neurilemmoma (1966-1976)
  • Neurofibromatosis 1 (1966-1991)
  • Neuroma, Acoustic (1978-1991)

MeSH Hierarchy

Tree Numbers

  1. C04w.557.465.625w.650w.595w.610w.500w
  2. C04w.557.580.600w.580w.590w.655w
  3. C04w.557.580.600w.610w.595w.610w.500w
  4. C04w.700w.631w.655w
  5. C09.218w.807.800.675w.500w
  6. C09.647.675w.500w
  7. C10w.292w.225.750w.500w
  8. C10w.292w.910.600w.500w
  9. C10w.562w.600w.750w
  10. C10w.574w.500.549w.700w
  11. C16w.320w.400.560w.700w
  12. C16w.320w.700w.633w.655w

AMA Style

References

  1. National Library of Medicine. Neurofibromatosis 2. Medical Subject Headings (MeSH). 2026. Unique ID D016518. http://id.nlm.nih.gov/mesh/2026/D016518
  2. Neurofibromatosis 2. In: Wikipedia. https://en.wikipedia.org/wiki/Neurofibromatosis_type_II
  3. Neurofibromatosis 2. In: Wikidata. https://www.wikidata.org/wiki/Q1935832