Diseases

Neuroleptic Malignant Syndrome

A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • NMS (Neuroleptic Malignant Syndrome)
  • NMSs (Neuroleptic Malignant Syndrome)
  • Neuroleptic Malignant Syndromes
  • Syndrome, Neuroleptic Malignant
  • Syndromes, Neuroleptic Malignant
  • Neuroleptic-Induced Neuroleptic Malignant Syndrome
  • Neuroleptic-Malignant Syndrome, Neuroleptic Induced
  • Neuroleptic Induced Neuroleptic Malignant Syndrome
  • Neuroleptic Malignant Syndrome, Neuroleptic Induced

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

caused by tranquilizing agents so do not use /chem ind

MeSH Record

History Note

1986(1985)

MeSH Record

Previous Indexing

  • Basal Ganglia Diseases (1979-1984)
  • Fever (1966-1984)
  • Malignant Hyperthermia (1973-1984)
  • Muscle Rigidity (1972-1984)
  • Tranquilizing Agents, Major (1975-1984)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.079w.737w
  2. C10w.720.737w
  3. C25.723.705.600w

MeSH Record

NLM Classification

WL 307

AMA Style

References

  1. National Library of Medicine. Neuroleptic Malignant Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D009459. http://id.nlm.nih.gov/mesh/2026/D009459
  2. Neuroleptic Malignant Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome
  3. Neuroleptic Malignant Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q1424956