Diseases

Neurosyphilis

Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)

MeSH Record

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MeSH Record

Synonyms

16 entry terms
  • Central Nervous System Syphilis
  • Syphilis, CNS
  • Syphilis, Central Nervous System
  • General Paralysis
  • General Paralysis of the Insane
  • General Paresis
  • General Paresis of the Insane
  • Juvenile Paresis
  • Neurosyphilis, Asymptomatic
  • Neurosyphilis, Gummatous
  • Neurosyphilis, Juvenile
  • Neurosyphilis, Secondary
  • Neurosyphilis, Symptomatic
  • Paralysis, General
  • Paretic Neurosyphilis
  • Secondary Neurosyphilis

MeSH Record

Aspects Covered

36 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, transmission, urine, veterinary, virology.

MeSH Record

History Note

1963; for GENERAL PARALYSIS & PARALYSIS, GENERAL use PARESIS 1963-93

MeSH Hierarchy

Tree Numbers

  1. C01w.150.252w.223.600w
  2. C01w.150.252w.400w.794.840w.500w.750w
  3. C01w.150.252w.400w.840w.500w.750w
  4. C01w.207w.180.600w
  5. C10w.228w.228w.180.600w

MeSH Record

NLM Classification

WC 165

AMA Style

References

  1. National Library of Medicine. Neurosyphilis. Medical Subject Headings (MeSH). 2026. Unique ID D009494. http://id.nlm.nih.gov/mesh/2026/D009494
  2. Neurosyphilis. In: Wikipedia. https://en.wikipedia.org/wiki/Neurosyphilis
  3. Neurosyphilis. In: Wikidata. https://www.wikidata.org/wiki/Q7888578