Chemicals and Drugs

Neurotransmitter Uptake Inhibitors

Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • Inhibitors, Neurotransmitter Uptake
  • Reuptake Inhibitors, Neurotransmitter
  • Transmitter Uptake Inhibitors, Neuronal
  • Uptake Inhibitors, Neurotransmitter
  • Inhibitors, Neurotransmitter Reuptake
  • Neurotransmitter Reuptake Inhibitors

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

general or unspecified; prefer specific groups or specific drugs; coordinate with specific neurotransmitters /physiol

MeSH Record

History Note

93; WAS TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92; NEUROTRANSMITTER UPTAKE INHIBITORS, INHIBITORS OF NEUROTRANSMITTER UPTAKE & UPTAKE INHIBITORS, NEUROTRANSMITTER were see TRANSMITTER UPTAKE INHIBITORS, NEURONAL 1985-92

MeSH Record

Previous Indexing

  • Cytoplasmic Granules (1966-1977)
  • Kinetics (1966-1984)
  • Nerve Endings (1966-1973)
  • Synapses (1966-1971)
  • Synaptic Vesicles (1972-1973)
  • Synaptosomes (1974-1984)

MeSH Hierarchy

Tree Numbers

  1. D27.505.519w.562.437
  2. D27.505.519w.625.600
  3. D27.505.696.577.600

MeSH Record

NLM Classification

QV 126

AMA Style

References

  1. National Library of Medicine. Neurotransmitter Uptake Inhibitors. Medical Subject Headings (MeSH). 2026. Unique ID D014179. http://id.nlm.nih.gov/mesh/2026/D014179
  2. Neurotransmitter Uptake Inhibitors. In: Wikidata. https://www.wikidata.org/wiki/Q50430184