Chemicals and Drugs

Nicorandil

A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.

Chemical Identity

Chemical Information

Molecular Formula
C8H9N3O4
Molecular Weight
211.17 g/mol
CAS Registry No.
65141-46-0
IUPAC Name
2-(pyridine-3-carbonylamino)ethyl nitrate
InChIKey
LBHIOVVIQHSOQN-UHFFFAOYSA-N
SMILES
C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-]
MeSH Unique ID
D020108
Source
PubChem CID 47528

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • 2-Nicotinamidethyl Nitrate
  • 2-Nicotinamidoethyl Nitrate
  • 2 Nicotinamidethyl Nitrate
  • 2 Nicotinamidoethyl Nitrate
  • Nitrate, 2-Nicotinamidethyl
  • Nitrate, 2-Nicotinamidoethyl
  • Adancor
  • Dancor
  • Ikorel
  • SG-75
  • SG 75
  • SG75

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1999; use NICORANDIL (NM) 1978-1998

MeSH Record

Previous Indexing

  • Niacinamide/analogs & derivatives (1978-1998)
  • Nitrates (1978-1982)

MeSH Hierarchy

Tree Numbers

  1. D02w.583w.575w
  2. D03w.066.515w.530w.498w
  3. D03w.383.725w.547w.530w.498w

AMA Style

References

  1. National Library of Medicine. Nicorandil. Medical Subject Headings (MeSH). 2026. Unique ID D020108. http://id.nlm.nih.gov/mesh/2026/D020108
  2. Nicorandil. In: Wikipedia. https://en.wikipedia.org/wiki/Nicorandil
  3. Nicorandil. In: Wikidata. https://www.wikidata.org/wiki/Q862989
  4. Nicorandil. In: PubChem Compound. CID 47528. https://pubchem.ncbi.nlm.nih.gov/compound/47528