Chemicals and Drugs

Nicotinamide-Nucleotide Adenylyltransferase

An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

12 entry terms
  • ATP-NMN Adenylyltransferase
  • NAD Pyrophosphorylase
  • NMN Adenylyltransferase
  • Nicotinamide Mononucleotide Adenylyltransferase
  • ATP NMN Adenylyltransferase
  • Adenylyltransferase, ATP-NMN
  • Adenylyltransferase, NMN
  • Adenylyltransferase, Nicotinamide Mononucleotide
  • Adenylyltransferase, Nicotinamide-Nucleotide
  • Mononucleotide Adenylyltransferase, Nicotinamide
  • Nicotinamide Nucleotide Adenylyltransferase
  • Pyrophosphorylase, NAD

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

98(79)

MeSH Record

Previous Indexing

  • Adenosine Triphosphate (1966-1978)
  • Nicotinamide Mononucleotide (1973-1978)
  • Nucleotidyltransferases (1966-1978)
  • Transferases (1966-1967)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.445w.600w
  2. D12.776w.157w.687.499w
  3. D12.776w.660w.720.499w

AMA Style

References

  1. National Library of Medicine. Nicotinamide-Nucleotide Adenylyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D009612. http://id.nlm.nih.gov/mesh/2026/D009612
  2. Nicotinamide-Nucleotide Adenylyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase
  3. Nicotinamide-Nucleotide Adenylyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q944680