Chemicals and Drugs

Nitroblue Tetrazolium

Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.

Chemical Identity

Chemical Information

Molecular Formula
C40H30N10O6+2
Molecular Weight
746.7 g/mol
CAS Registry No.
7695-60-5
IUPAC Name
2-[2-methoxy-4-[3-methoxy-4-[3-(4-nitrophenyl)-5-phenyltetrazol-2-ium-2-yl]phenyl]phenyl]-3-(4-nitrophenyl)-5-phenyltetrazol-2-ium
InChIKey
JPXMTWWFLBLUCD-UHFFFAOYSA-N
SMILES
COC1=C(C=CC(=C1)C2=CC(=C(C=C2)[N+]3=NC(=NN3C4=CC=C(C=C4)[N+](=O)[O-])C5=CC=CC=C5)OC)[N+]6=NC(=NN6C7=CC=C(C=C7)[N+](=O)[O-])C8=CC=CC=C8
MeSH Unique ID
D009580
Source
PubChem CID 9282

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Nitro-BT
  • Nitrotetrazolium Blue
  • Tetrazolium Nitroblue
  • Blue, Nitrotetrazolium
  • Nitroblue, Tetrazolium
  • Tetrazolium, Nitroblue

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analogs & derivatives, analysis, chemical synthesis, chemistry, classification, economics, history, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity.

MeSH Record

History Note

91(75); was see under TETRAZOLIUM SALTS 1975-90

MeSH Record

Previous Indexing

  • Nitro Compounds (1973-1974)
  • Tetrazolium Salts (1972-1974)

MeSH Hierarchy

Tree Number

  1. D03w.383.129w.617.700.500

AMA Style

References

  1. National Library of Medicine. Nitroblue Tetrazolium. Medical Subject Headings (MeSH). 2026. Unique ID D009580. http://id.nlm.nih.gov/mesh/2026/D009580
  2. Nitroblue Tetrazolium. In: Wikidata. https://www.wikidata.org/wiki/Q27107534
  3. Nitroblue Tetrazolium. In: PubChem Compound. CID 9282. https://pubchem.ncbi.nlm.nih.gov/compound/9282