Chemicals and Drugs

Nodal Signaling Ligands

Members of the transforming growth factor superfamily that play a role in pattern formation and differentiation during the pregastrulation and GASTRULATION stages of chordate development. Several nodal signaling ligands are specifically involved in the genesis of left-right asymmetry during development. The protein group is named after a critical region of the vertebrate embryo PRIMITIVE STREAK referred to as HENSEN'S NODE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Members of the transforming growth factor superfamily that play a role in pattern formation and differentiation during the pregastrulation and GASTRULATION stages of chordate development. Several nodal signaling ligands are specifically involved in the genesis of left-right asymmetry during development. The protein group is named after a critical region of the vertebrate embryo PRIMITIVE STREAK referred to as HENSEN'S NODE.

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Synonyms

2 entry terms
  • Nodal Signaling Proteins
  • Signaling Proteins, Nodal

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2009

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AMA Style

References

  1. National Library of Medicine. Nodal Signaling Ligands. Medical Subject Headings (MeSH). 2026. Unique ID D055456. http://id.nlm.nih.gov/mesh/2026/D055456
  2. Nodal Signaling Ligands. In: Wikidata. https://www.wikidata.org/wiki/Q76390609