Structured Summary
Abstract
A nuclear co-repressor protein that shows specificity for RETINOIC ACID RECEPTORS and THYROID HORMONE RECEPTORS. The dissociation of this co-repressor from nuclear receptors is generally ligand-dependent, but can also occur by way of its phosphorylation by members of the MAP KINASE SIGNALING SYSTEM. The protein contains two nuclear receptor interaction domains and four repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 1.
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Classification
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Synonyms
11 entry terms
- SMRT Co-repressor
- Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor
- T3 Receptor-associating Factor
- TRAC Co-repressor
- Co-repressor, SMRT
- Co-repressor, TRAC
- Nuclear Receptor Co Repressor 2
- Receptor-associating Factor, T3
- SMRT Co repressor
- T3 Receptor associating Factor
- TRAC Co repressor
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2010(1995)
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AMA Style
References
- National Library of Medicine. Nuclear Receptor Co-Repressor 2. Medical Subject Headings (MeSH). 2026. Unique ID D056985. http://id.nlm.nih.gov/mesh/2026/D056985
- Nuclear Receptor Co-Repressor 2. In: Wikidata. https://www.wikidata.org/wiki/Q22683558