Chemicals and Drugs

Oncogene Protein pp60(v-src)

A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.

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Classification

Broader headings

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See Also

MeSH Record

Synonyms

21 entry terms
  • Avian Sarcoma Virus-Transforming Protein
  • Oncogene Protein pp60(src)
  • Oncogene Protein src
  • Phosphoprotein pp60(v-src)
  • Rous Sarcoma Virus-Transforming Protein pp60(v-src)
  • p60(v-src)
  • pp60 v-src
  • pp60(v-src)
  • src Oncogene Product pp60
  • src Oncogene Protein pp60
  • v-src Protein
  • v-src Protein pp60
  • Avian Sarcoma Virus Transforming Protein
  • Protein pp60, v-src
  • Protein src, Oncogene
  • pp60 v src
  • pp60, v-src Protein
  • src, Oncogene Protein
  • v src Protein
  • v src Protein pp60
  • v-src, pp60

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91; was ONCOGENE PROTEIN PP60(SRC) 1990; PP60(SRC) was see ONCOGENE PROTEIN PP60(SRC) 1990

MeSH Record

Previous Indexing

  • Retroviridae Proteins (1986-1989)
  • Viral Proteins (1981-1985)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.800w.472
  2. D12.776w.476.568w.800w.472
  3. D12.776w.624.664.520.750w.760
  4. D12.776w.964w.700.750w.760
  5. D12.776w.964w.775.750w.760

AMA Style

References

  1. National Library of Medicine. Oncogene Protein pp60(v-src). Medical Subject Headings (MeSH). 2026. Unique ID D015688. http://id.nlm.nih.gov/mesh/2026/D015688
  2. Oncogene Protein pp60(v-src). In: Wikidata. https://www.wikidata.org/wiki/Q78346489