Structured Summary
Abstract
A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
Chemical Identity
Chemical Information
- Molecular Formula
- C29H53NO5
- Molecular Weight
- 495.7 g/mol
- CAS Registry No.
- 96829-58-2
- IUPAC Name
- [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate
- InChIKey
- AHLBNYSZXLDEJQ-FWEHEUNISA-N
- SMILES
- CCCCCCCCCCC[C@@H](C[C@H]1[C@@H](C(=O)O1)CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
- MeSH Unique ID
- D000077403
- Source
- PubChem CID 3034010
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
8 entry terms
- THLP
- Tetrahydrolipastatin
- Tetrahydrolipstatin
- 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
- Alli
- Ro-18-0647
- Xenical
- Ro 18 0647
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1988)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Orlistat. Medical Subject Headings (MeSH). 2026. Unique ID D000077403. http://id.nlm.nih.gov/mesh/2026/D000077403
- Orlistat. In: Wikipedia. https://en.wikipedia.org/wiki/Orlistat
- Orlistat. In: Wikidata. https://www.wikidata.org/wiki/Q424163
- Orlistat. In: PubChem Compound. CID 3034010. https://pubchem.ncbi.nlm.nih.gov/compound/3034010