Chemicals and Drugs

Osteopontin

A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • Bone Sialoprotein 1
  • Bone Sialoprotein I
  • Secreted Phosphoprotein 1
  • Sialoprotein 1
  • Sialoprotein 1, Bone
  • Sialoprotein I, Bone
  • Uropontin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007(1987)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.950w.837
  2. D12.644w.276.374w.625
  3. D12.776w.395w.700w.837
  4. D12.776w.467.374w.625
  5. D12.776w.860w.300.762
  6. D23.529.374w.625

AMA Style

References

  1. National Library of Medicine. Osteopontin. Medical Subject Headings (MeSH). 2026. Unique ID D053495. http://id.nlm.nih.gov/mesh/2026/D053495
  2. Osteopontin. In: Wikidata. https://www.wikidata.org/wiki/Q24771226