Chemicals and Drugs

Oxamniquine

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)

Chemical Identity

Chemical Information

Molecular Formula
C14H21N3O3
Molecular Weight
279.33 g/mol
CAS Registry No.
21738-42-1
IUPAC Name
[7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl]methanol
InChIKey
XCGYUJZMCCFSRP-UHFFFAOYSA-N
SMILES
CC(C)NCC1CCC2=CC(=C(C=C2N1)[N+](=O)[O-])CO
MeSH Unique ID
D010073
Source
PubChem CID 4612

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Oxaminiquine
  • UK-4271
  • UK 4271
  • UK4271

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under NITROQUINOLINES 1975-90

MeSH Record

Previous Indexing

  • Nitro Compounds (1973-1974)
  • Propylamines (1973-1974)
  • Quinolines (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.810.350.600w
  2. D03w.633.100.810.470.600w

AMA Style

References

  1. National Library of Medicine. Oxamniquine. Medical Subject Headings (MeSH). 2026. Unique ID D010073. http://id.nlm.nih.gov/mesh/2026/D010073
  2. Oxamniquine. In: Wikipedia. https://en.wikipedia.org/wiki/Oxamniquine
  3. Oxamniquine. In: Wikidata. https://www.wikidata.org/wiki/Q682497
  4. Oxamniquine. In: PubChem Compound. CID 4612. https://pubchem.ncbi.nlm.nih.gov/compound/4612