Structured Summary
Abstract
Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
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Synonyms
23 entry terms
- PHD Domains
- PHD Finger Domain
- PHD Fingers
- PHD Motif
- PHD Motifs
- PHD Zinc Finger
- Domain, PHD
- Domain, PHD Finger
- Domains, PHD
- Domains, PHD Finger
- Finger Domain, PHD
- Finger Domains, PHD
- Finger, PHD
- Finger, PHD Zinc
- Fingers, PHD
- Fingers, PHD Zinc
- Motif, PHD
- Motifs, PHD
- PHD Domain
- PHD Finger
- PHD Finger Domains
- Zinc Finger, PHD
- Zinc Fingers, PHD
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Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
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History Note
2018
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Previous Indexing
- Amino Acid Sequence (1995-2017)
- Molecular Sequence Data (1995-2017)
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AMA Style
References
- National Library of Medicine. PHD Zinc Fingers. Medical Subject Headings (MeSH). 2026. Unique ID D000075925. http://id.nlm.nih.gov/mesh/2026/D000075925
- PHD Zinc Fingers. In: Wikipedia. https://en.wikipedia.org/wiki/PHD_finger
- PHD Zinc Fingers. In: Wikidata. https://www.wikidata.org/wiki/Q7119217