Structured Summary
Abstract
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
MeSH Record
Classification
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
10 entry terms
- MMAC1 Protein
- Mutated In Multiple Advanced Cancers 1 Protein
- PTEN Phosphatase
- PTEN Protein
- PTEN Protein Phosphatase
- Phosphatase and Tensin Homologue on Chromosome Ten Protein
- Phosphatase, PTEN
- Phosphatase, PTEN Protein
- Phosphohydrolase, PTEN
- Protein Phosphatase, PTEN
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1997)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. PTEN Phosphohydrolase. Medical Subject Headings (MeSH). 2026. Unique ID D051059. http://id.nlm.nih.gov/mesh/2026/D051059
- PTEN Phosphohydrolase. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_3-phosphatase
- PTEN Phosphohydrolase. In: Wikidata. https://www.wikidata.org/wiki/Q7187457