Chemicals and Drugs

Palonosetron

Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting.

Chemical Identity

Chemical Information

Molecular Formula
C19H24N2O
Molecular Weight
296.4 g/mol
CAS Registry No.
135729-61-2
IUPAC Name
(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one
InChIKey
CPZBLNMUGSZIPR-NVXWUHKLSA-N
SMILES
C1C[C@@H]2CN(C(=O)C3=CC=CC(=C23)C1)[C@@H]4CN5CCC4CC5
MeSH Unique ID
D000077924
Source
PubChem CID 6337614

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

31 entry terms
  • 2-QHBIQO
  • 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
  • Aloxi
  • Palonosetron Hydrochloride
  • Palonosetron, (3R)-
  • Palonosetron, (R-(R*,R*))-isomer
  • Palonosetron, (R-(R*,S*))-isomer
  • Palonosetron, (S-(R*,S*))-isomer
  • RS 25233-197
  • RS 25233-198
  • RS 25259
  • RS 25259-197
  • RS 25259-198
  • RS-25233-197
  • RS-25233-198
  • RS-25259
  • RS-25259-197
  • RS-25259-198
  • RS 25233 197
  • RS 25233 198
  • RS 25233197
  • RS 25233198
  • RS 25259 197
  • RS 25259 198
  • RS 25259197
  • RS 25259198
  • RS25233197
  • RS25233198
  • RS25259
  • RS25259197
  • RS25259198

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1993)

MeSH Hierarchy

Tree Numbers

  1. D03w.605.687.319w
  2. D03w.633.100.531.629w

AMA Style

References

  1. National Library of Medicine. Palonosetron. Medical Subject Headings (MeSH). 2026. Unique ID D000077924. http://id.nlm.nih.gov/mesh/2026/D000077924
  2. Palonosetron. In: Wikipedia. https://en.wikipedia.org/wiki/Palonosetron
  3. Palonosetron. In: Wikidata. https://www.wikidata.org/wiki/Q419841
  4. Palonosetron. In: PubChem Compound. CID 6337614. https://pubchem.ncbi.nlm.nih.gov/compound/6337614