Chemicals and Drugs

Parathyroid Hormone-Related Protein

A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

16 entry terms
  • Hypercalcemic Hormone of Malignancy
  • PTH Like Tumor Factor
  • PTH-Like Protein
  • PTH-Related Peptide
  • PTHrP
  • Parathyroid Hormone Like Tumor Factor
  • Parathyroid Hormone-Like Protein
  • Parathyroid Hormone-Related Peptide
  • Tumor Hypercalcemic Factor
  • Hormone-Related Protein, Parathyroid
  • Hypercalcemic Factor, Tumor
  • PTH Like Protein
  • PTH Related Peptide
  • Parathyroid Hormone Like Protein
  • Parathyroid Hormone Related Peptide
  • Parathyroid Hormone Related Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

see SCR for organism specific terms

MeSH Record

History Note

2004; use PARATHYROID HORMONE-RELATED PROTEIN (NM) 1987-2003

MeSH Record

Previous Indexing

  • Peptide Hormones (2003)
  • Proteins (1987-2002)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.591w
  2. D12.644w.276.908w
  3. D12.644w.548w.588w
  4. D12.776w.467.890w
  5. D23.529.890w

AMA Style

References

  1. National Library of Medicine. Parathyroid Hormone-Related Protein. Medical Subject Headings (MeSH). 2026. Unique ID D044162. http://id.nlm.nih.gov/mesh/2026/D044162
  2. Parathyroid Hormone-Related Protein. In: Wikipedia. https://en.wikipedia.org/wiki/Parathyroid_hormone-related_protein
  3. Parathyroid Hormone-Related Protein. In: Wikidata. https://www.wikidata.org/wiki/Q2007821