Chemicals and Drugs

Paxillin

Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.

MeSH Record

Classification

Broader headings

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MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1991)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.316
  2. D12.776w.157w.057w.092
  3. D12.776w.476.024w.397
  4. D12.776w.512.374
  5. D12.776w.744w.665

AMA Style

References

  1. National Library of Medicine. Paxillin. Medical Subject Headings (MeSH). 2026. Unique ID D051419. http://id.nlm.nih.gov/mesh/2026/D051419
  2. Paxillin. In: Wikidata. https://www.wikidata.org/wiki/Q24742139