Chemicals and Drugs

Peroxisomal Multifunctional Protein-2

A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • 17-beta-Hydroxysteroid Dehydrogenase 4
  • 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
  • Peroxisomal Multifunctional Enzyme Type 2
  • 17 beta Hydroxysteroid Dehydrogenase 4
  • 4, 17-beta-Hydroxysteroid Dehydrogenase
  • Dehydrogenase 4, 17-beta-Hydroxysteroid
  • Multifunctional Protein-2, Peroxisomal
  • Peroxisomal Multifunctional Protein 2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Record

Previous Indexing

  • 17-Hydroxysteroid Dehydrogenases (1997-2013)
  • Enoyl-CoA Hydratase (1997-2013)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.520w.241.300w.275.500
  2. D08.811w.641.812
  3. D08.811w.682w.047w.436w.375w.640
  4. D08.811w.682w.047w.820.150w.926

AMA Style

References

  1. National Library of Medicine. Peroxisomal Multifunctional Protein-2. Medical Subject Headings (MeSH). 2026. Unique ID D064029. http://id.nlm.nih.gov/mesh/2026/D064029
  2. Peroxisomal Multifunctional Protein-2. In: Wikidata. https://www.wikidata.org/wiki/Q21117486