Chemicals and Drugs

Phalloidine

Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.

Chemical Identity

Chemical Information

Molecular Formula
C35H48N8O11S
Molecular Weight
788.9 g/mol
CAS Registry No.
17466-45-4
IUPAC Name
(1S,14R,18S,20S,23S,28S,31S,34R)-28-[(2R)-2,3-dihydroxy-2-methylpropyl]-18-hydroxy-34-[(1S)-1-hydroxyethyl]-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone
InChIKey
KPKZJLCSROULON-QKGLWVMZSA-N
SMILES
C[C@H]1C(=O)N[C@H]2CC3=C(NC4=CC=CC=C34)SC[C@@H](C(=O)N5C[C@H](C[C@H]5C(=O)N1)O)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)C[C@](C)(CO)O)C)[C@H](C)O
MeSH Unique ID
D010590
Source
PubChem CID 441542

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Phalloidin

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under OLIGOPEPTIDES 1975-90

MeSH Record

Previous Indexing

  • Food Poisoning (1966-1967)
  • Mushroom Poisoning (1968-1974)
  • Mushrooms (1966-1967)
  • Peptides (1966-1972)
  • Peptides, Cyclic (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D04w.345w.566w.735w
  2. D12.644w.456w.735w
  3. D12.644w.641w.735w
  4. D23.946w.587w.755w

AMA Style

References

  1. National Library of Medicine. Phalloidine. Medical Subject Headings (MeSH). 2026. Unique ID D010590. http://id.nlm.nih.gov/mesh/2026/D010590
  2. Phalloidine. In: Wikipedia. https://en.wikipedia.org/wiki/Phalloidin
  3. Phalloidine. In: Wikidata. https://www.wikidata.org/wiki/Q2266164
  4. Phalloidine. In: PubChem Compound. CID 441542. https://pubchem.ncbi.nlm.nih.gov/compound/441542