Chemicals and Drugs

Phencyclidine

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Chemical Identity

Chemical Information

Molecular Formula
C17H25N
Molecular Weight
243.4 g/mol
CAS Registry No.
77-10-1
IUPAC Name
1-(1-phenylcyclohexyl)piperidine
InChIKey
JTJMJGYZQZDUJJ-UHFFFAOYSA-N
SMILES
C1CCC(CC1)(C2=CC=CC=C2)N3CCCCC3
MeSH Unique ID
D010622
Source
PubChem CID 6468

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

13 entry terms
  • 1-(1-Phenylcyclohexyl)piperidine
  • Angel Dust
  • Dust, Angel
  • CL-395
  • GP-121
  • Phencyclidine Hydrobromide
  • Phencyclidine Hydrochloride
  • Sernyl
  • Serylan
  • CL 395
  • CL395
  • GP 121
  • GP121

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

73(64); was see under PIPERIDINES 1969-72; was see under PIPERIDINES & ANESTHETICS 1968; was see under ANESTHETICS 1967

MeSH Record

Previous Indexing

  • Anesthetics (1966-1972)
  • Piperidines (1968-1972)

MeSH Hierarchy

Tree Number

  1. D03w.383.621.699w

MeSH Record

NLM Classification

QV 77.7

AMA Style

References

  1. National Library of Medicine. Phencyclidine. Medical Subject Headings (MeSH). 2026. Unique ID D010622. http://id.nlm.nih.gov/mesh/2026/D010622
  2. Phencyclidine. In: Wikipedia. https://en.wikipedia.org/wiki/Phencyclidine
  3. Phencyclidine. In: Wikidata. https://www.wikidata.org/wiki/Q407324
  4. Phencyclidine. In: PubChem Compound. CID 6468. https://pubchem.ncbi.nlm.nih.gov/compound/6468