Structured Summary
Abstract
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
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Classification
Broader headings
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Synonyms
4 entry terms
- SHIP Phosphatases
- Src Homology 2 Domain-Containing Inositol Phosphatases
- Phosphatases, SHIP
- Src Homology 2 Domain Containing Inositol Phosphatases
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Phosphoric Monoester Hydrolases (1996-2016)
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AMA Style
References
- National Library of Medicine. Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases. Medical Subject Headings (MeSH). 2026. Unique ID D000072183. http://id.nlm.nih.gov/mesh/2026/D000072183
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases. In: Wikidata. https://www.wikidata.org/wiki/Q10640506