Chemicals and Drugs

Phosphatidylinositol 4,5-Diphosphate

A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)

Chemical Identity

Chemical Information

Molecular Formula
C47H85O19P3
Molecular Weight
1047.1 g/mol
CAS Registry No.
245126-95-8
IUPAC Name
[(2R)-1-[hydroxy-[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-diphosphonooxycyclohexyl]oxyphosphoryl]oxy-3-octadecanoyloxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
InChIKey
CNWINRVXAYPOMW-FCNJXWMTSA-N
SMILES
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O[C@@H]1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)OP(=O)(O)O)OP(=O)(O)O)O)O)OC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC
MeSH Unique ID
D019269
Source
PubChem CID 5497157

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

11 entry terms
  • Phosphatidylinositol 4,5-Biphosphate
  • Phosphatidylinositol Phosphate, PtdIns(4,5)P2
  • Phosphatidylinositol-4,5-Biphosphate
  • PtIns 4,5-P2
  • PtdIns(4,5)P2
  • PtdInsP
  • PtdInsP2
  • 4,5-Biphosphate, Phosphatidylinositol
  • 4,5-Diphosphate, Phosphatidylinositol
  • Phosphatidylinositol 4,5 Biphosphate
  • Phosphatidylinositol 4,5 Diphosphate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

97; see PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE (NM) 1981-96

MeSH Record

Previous Indexing

  • Phosphatidylinositol Phosphates (1994-1996)
  • Phosphatidylinositols (1981-1993)

MeSH Hierarchy

Tree Number

  1. D10w.570w.755w.375.760w.400w.942w.625.900w

AMA Style

References

  1. National Library of Medicine. Phosphatidylinositol 4,5-Diphosphate. Medical Subject Headings (MeSH). 2026. Unique ID D019269. http://id.nlm.nih.gov/mesh/2026/D019269
  2. Phosphatidylinositol 4,5-Diphosphate. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate
  3. Phosphatidylinositol 4,5-Diphosphate. In: Wikidata. https://www.wikidata.org/wiki/Q3083814
  4. Phosphatidylinositol 4,5-Diphosphate. In: PubChem Compound. CID 5497157. https://pubchem.ncbi.nlm.nih.gov/compound/5497157