Chemicals and Drugs

Phosphoadenosine Phosphosulfate

3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.

Chemical Identity

Chemical Information

Molecular Formula
C10H15N5O13P2S
Molecular Weight
507.27 g/mol
CAS Registry No.
482-67-7
IUPAC Name
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl sulfo hydrogen phosphate
InChIKey
GACDQMDRPRGCTN-KQYNXXCUSA-N
SMILES
C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OS(=O)(=O)O)OP(=O)(O)O)O)N
MeSH Unique ID
D010724
Source
PubChem CID 10214

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

3 entry terms
  • Adenosine-3'-phosphate-5'-Phosphosulfate
  • Adenosine 3' phosphate 5' Phosphosulfate
  • Phosphosulfate, Phosphoadenosine

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under ADENINE NUCLEOTIDES 1975-90

MeSH Record

Previous Indexing

  • Adenosine Monophosphate (1973-1978)
  • Organophosphorus Compounds (1973-1974)
  • Sulfuric Acids (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.646.138.850w
  2. D13.695w.667.138.850w
  3. D13.695w.827w.068.850w

AMA Style

References

  1. National Library of Medicine. Phosphoadenosine Phosphosulfate. Medical Subject Headings (MeSH). 2026. Unique ID D010724. http://id.nlm.nih.gov/mesh/2026/D010724
  2. Phosphoadenosine Phosphosulfate. In: Wikipedia. https://en.wikipedia.org/wiki/3%27-Phosphoadenosine-5%27-phosphosulfate
  3. Phosphoadenosine Phosphosulfate. In: Wikidata. https://www.wikidata.org/wiki/Q229811
  4. Phosphoadenosine Phosphosulfate. In: PubChem Compound. CID 10214. https://pubchem.ncbi.nlm.nih.gov/compound/10214