Chemicals and Drugs

Phosphoenolpyruvate Sugar Phosphotransferase System

The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.

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Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • Phosphoenolpyruvate Hexose Phosphotransferases
  • Phosphoenolpyruvate-Glycose Phosphotransferase System
  • Hexose Phosphotransferases, Phosphoenolpyruvate
  • Phosphoenolpyruvate Glycose Phosphotransferase System
  • Phosphotransferase System, Phosphoenolpyruvate-Glycose
  • Phosphotransferases, Phosphoenolpyruvate Hexose
  • System, Phosphoenolpyruvate-Glycose Phosphotransferase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

80

MeSH Record

Previous Indexing

  • Phosphoenolpyruvate (1972-1979)
  • Phosphoric Acids (1968-1971)
  • Phosphotransferases (1966-1979)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.562w.484
  2. D08.811w.600w.700
  3. D08.811w.913w.696w.620.650

AMA Style

References

  1. National Library of Medicine. Phosphoenolpyruvate Sugar Phosphotransferase System. Medical Subject Headings (MeSH). 2026. Unique ID D010731. http://id.nlm.nih.gov/mesh/2026/D010731
  2. Phosphoenolpyruvate Sugar Phosphotransferase System. In: Wikidata. https://www.wikidata.org/wiki/Q21199241