Chemicals and Drugs

Phosphonoacetic Acid

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.

Chemical Identity

Chemical Information

Molecular Formula
C2H5O5P
Molecular Weight
140.03 g/mol
CAS Registry No.
4408-78-0
IUPAC Name
2-phosphonoacetic acid
InChIKey
XUYJLQHKOGNDPB-UHFFFAOYSA-N
SMILES
C(C(=O)O)P(=O)(O)O
MeSH Unique ID
D010746
Source
PubChem CID 546

MeSH Record

Classification

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • Phosphonacetic Acid
  • Disodium Phosphonoacetate
  • Fosfonet Sodium
  • Phosphonoacetate
  • Phosphonoacetate, Disodium

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90(78); was see under ORGANOPHOSPHORUS COMPOUNDS 1978-89

MeSH Record

Previous Indexing

  • Organophosphorus Compounds (1972-1977)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Phosphonoacetic Acid. Medical Subject Headings (MeSH). 2026. Unique ID D010746. http://id.nlm.nih.gov/mesh/2026/D010746
  2. Phosphonoacetic Acid. In: Wikidata. https://www.wikidata.org/wiki/Q27093778
  3. Phosphonoacetic Acid. In: PubChem Compound. CID 546. https://pubchem.ncbi.nlm.nih.gov/compound/546