Chemicals and Drugs

Phosphoribosylaminoimidazolecarboxamide Formyltransferase

An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the purine de novo synthesis pathway. It requires the cofactor N(10)-FORMYLTETRAHYDROFOLATE as the formyl donor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the purine de novo synthesis pathway. It requires the cofactor N(10)-FORMYLTETRAHYDROFOLATE as the formyl donor.

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Classification

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MeSH Record

Synonyms

9 entry terms
  • AICAR Formyltransferase
  • AICAR Transformylase
  • AICARTFase
  • Aminoimidazolecarboxamide Ribonucleotide Transformylase
  • Formyltransferase, AICAR
  • Formyltransferase, Phosphoribosylaminoimidazolecarboxamide
  • Ribonucleotide Transformylase, Aminoimidazolecarboxamide
  • Transformylase, AICAR
  • Transformylase, Aminoimidazolecarboxamide Ribonucleotide

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1980); use FORMIC ACIDS 1974-1980, AMINOIMIDAZOLE CARBOXAMIDE 1979-1980, IMIDAZOLES 1974-1979, PENTOSEPHOSPHATES 1974-1979, TRANSFERASES 1974-1979

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References

  1. National Library of Medicine. Phosphoribosylaminoimidazolecarboxamide Formyltransferase. Medical Subject Headings (MeSH). 2026. Unique ID D051027. http://id.nlm.nih.gov/mesh/2026/D051027
  2. Phosphoribosylaminoimidazolecarboxamide Formyltransferase. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolecarboxamide_formyltransferase
  3. Phosphoribosylaminoimidazolecarboxamide Formyltransferase. In: Wikidata. https://www.wikidata.org/wiki/Q3748973